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Title   간외담도암에 있어서 Chromogranin A 발현의 의의 ( Significance of Chromogranin - A expression in the Bile Duct Cancer )
Publicationinfo   1993 Jan; 025(04): 501-507.
Key_word   Bile duct cancer, Neuraendocrine differentiation, Chromogranin-A
Full-Text  
Abstract   To investigate whether neuroendocrine differentiation exists and has any clinical significance in cancers of the common bile duct, paraffin sections of samples from 37 cases of these tumors resected from 1986 to 1990 were immunostained for chromogranin-A(CgA). Thirteen tumors(35%) had tumor cells stained with CgA. Although the patients with CgA positive tumors were rather younger, no other difference was noted between CgA negative group and CgA positive group in clinico-pathologic characteristics including sex, extent of disease, histologic and gross types, location of tumor. The patients were analysed for survival time according to the extent of disease and CgA positivity. Prognosis of CgA positive tumor was significantly worse than that of CgA negative tumor in the cases without lymph node metastasis or adjacent organ invasion. This study suggests that the incidence of neuroendocrine differentiation is rather high and neuroendocrine differentiation is associated with poor prognosis in cancers of the common bile duct.
저 자   김선회(Sun Whe Kim),김우호(Woo Ho Kim),조삼제(Sam Jae Cho),박용현(Yong Hyun Park)